Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

The Prevalence of Autoimmune Disease on the Thyroid | Wellness Clinic

The thyroid gland plays a major part in the human body; it’s in charge of creating the hormones necessary for providing our body’s energy levels for an active life. These hormones have a critical impact on the development and growth of our body. At the same time, however, the thyroid is highly vulnerable to autoimmune thyroid diseases (AITDs).

 

Why is the thyroid gland vulnerable to autoimmune thyroid disease?

 

Autoimmune thyroid diseases often occur as a result of genetic factors. These seem to affect disease progression after the thyroid gland becomes the target of autoimmunity cells. It can create a large array of cytokines, adhesion molecules, and also growth factors. The susceptibility of the thyroid to AITDs can come from the complexity of hormonal synthesis, oligoelement conditions and particular capabilities of the defense mechanisms of the thyroid.

 

Genetic Factors for Thyroid Disease

 

The thyroid gland is essential in the human body due to it’s production of thyroid hormones. These compounds have fundamental effects, playing critical roles in somatic growth, brain development, bone maturation, and the mRNA synthesis of more than 100 proteins which govern each and every physiological function of the body.

 

The incidence of chronic autoimmune thyroiditis, abbreviated as CAT, and Graves’ disease, another autoimmune thyroid disease, has increased dramatically over the last few decades, afflicting up to 5 percent of the overall population. Chronic autoimmune thyroiditis has become the most common cause of hypothyroidism, according to recent studies.

 

Initial research on the association between early fetal nourishment and the pathogenesis of autoimmune thyroid disease has led to some controversial data. In twin studies, Phillips et al. found that one monozygotic twins, the smaller twin, had greater levels of thyroid peroxidase (TPO) antibodies. In instances of both type 1 and type 2 diabetes, the hypothesis suggests excess weight and obesity in children can be a major contributing factor to thyroid disease, even among the population of children with type 1 diabetes, those who were more overweight or obese demonstrated a higher prevalence of thyroid and autoimmunity issues. Obese children have also been found to have increased interferon (IFN)-?-secreting T helper cells along with altered thyroid structure and hormonal status.

 

Recent advances in genome-wide research have made it feasible to effectively identify complicated genes. Using both the candidate gene approach and whole-genome linkage studies, 6 AITD susceptibility genes have been identified and verified; the very first group includes the immunomodulatory gene products HLA-DR, CD40, cytotoxic T lymphocyte-associated variable (CTLA-4), and protein tyrosine phosphatase 22 (PTPN22), and the second category involves the thyroid-specific receptor goods thyroglobulin (Tg) and also thyroid-stimulating hormone receptor (TSHR).

 

Genetic factors predominate as the leading cause of thyroid dysfunction, accounting for roughly 80 percent of the odds of developing autoimmune thyroid diseases, whereas at least 20 percent are due to environmental or other variables. On the history of AITDs, a number of research studies have been published in the last few decades.

 

http://www.karger.com/WebMaterial/ShowPic/222654

 

An increased frequency of AITDs is reported in Turner syndrome and in additional nondisjunctional chromosomal disorders such as in Down syndrome and Klinefelter syndrome. The concept that autoimmunity can lead to the survival of a fetus with chromosomal aneuploidy is fascinating but remains unproven. The most prevalent disorder in Turner syndrome appears to be chronic autoimmune thyroiditis, with a reported thyroid autoantibody incidence of 30. Hypothyroidism of autoimmune origin is indeed common in TS that every other TS girl will likely develop hypothyroidism.

 

Analyzing the Thyroid Cell

 

The thyroid cell produces a variety of immunologically active factors, as shown on Table 1, and has complicated nutrient conditions for hormonal synthesis, as shown on Table 2, both of which influence susceptibility to AITDs. It is increasingly clear that the target thyroid cells interact with the body in ways that look defensive and protective, yet they can malfunction and exacerbate under circumstances that are particular, according to the research.

 

Table 1

http://www.karger.com/WebMaterial/ShowPic/222656

 

Table 2

 

http://www.karger.com/WebMaterial/ShowPic/222655

 

In the majority of human autoimmune disorders, the events which trigger autoimmunity remain unknown. It is unclear whether results mostly from an immune defect, are secondary to target organ alterations, or even both. The thyroid gland demonstrated increased oxidation and iodine uptake prior to infiltration concomitant in the case of autoimmune thyroid disease. Modifying thyroid function influences the growth of thyroid autoimmunity. The thyroid, contrary to other cells from the endocrine system, is exceptional in function since it releases hormonal goods on its basal surface instead of its surface, hence allowing for the proper transportation of iodine which is essential across the cell.

 

Thyroid cells are capable of producing different factors (Table 1), such as IGF I, IGF II, and EGF, which could stimulate angiogenesis. The half-life of those molecules is short and they induce only localized (nonsystemic) effects. Thyroid follicular cells secrete several necessary growth factors. The expression of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-3 (LFA-3) by thyroid cells is enhanced by IFN-?, tumor necrosis factor (TNF), and interleukin (IL)-1. Thyroid cells express CD44, which functions as a homing receptor for hyaluronan, mediates leukocyte rolling (the very first step in tissue homing), and may (like ICAM-1) induce lymphocyte activation under certain circumstances. Thyroid cells are now known to produce many cytokines (particularly after stimulation with IL-1), including IL-1, IL-6, IL-8, IL-12, IL-13, and IL-15. Activated lymphocytes can create TSH.

 

Low dose substance tolerance can easily be altered, and the thyroid gland is not well taken by the immune system. Autoantigens in autoimmune thyroid disease, as in other autoimmune endocrine disorders, include tissue-specific membrane receptors, enzymes, and secreted hormones. Mixed cellular and antibody autoimmune responses are probably pathogenic to some level. Circulating anti-Tg autoantibodies can also be present in GD and CAT, as are autoantibodies to triiodothyronine (T3) and thyroxine (T4). The human (h) TSHR is the principal antigenic target in autoimmune hyperthyroidism. The TPO autoantibody appears to be unlikely to have much pathogenic importance as it’s restricted access to TPO is due to its location inside the cell. What’s more, anti-TPO autoantibodies don’t inhibit the action of this enzyme. Therefore, their clinical significance is principally to record thyroid gland autoimmunity.

 

In humans, excess thyroid gland hormones can lead to the attenuation of natural killer (NK) cell activity, which in theory could cause the continuation of an autoimmune disease. Upon return to some euthyroid status along with the consequent normalization of NK activity, a reversion to management of this abnormal immune reaction would occur with perpetuation of GD. Furthermore, an anti-idiotype may be the agonist for the original antigen. Therefore, an antibody to a antibody (anti-idiotype) into TSH may pertain to the TSHR and stimulate the thyroid gland. A more likely hypothesis is that anti-idiotypic antibodies are rarely generated at a detectable degree. Hodkinson et al. recently found a positive association between thyroid hormone concentration and NK-like T cells in the elderly.

 

Antigen Presentation

 

Bottazzo et al. first indicated that antigen presentation by HLA-DR-expressing thyroid gland hormones may be a vital aspect of thyroid autoimmune disease. It rapidly became clear in the research that the only stimulus capable of causing MHC class II expression on thyroid cells was the T cell cytokine IFN-?. Regular cells react precisely the same as AITD thyroid gland in IFN-?, and in animal models of AITDs, class II expression on thyroid cells is constantly followed by the amount of lymphocytes. Along with inducing MHC class II expression, IFN-? increases MHC class I expression on thyroid cells, thus allowing the recognition of thyroid cells from cytotoxic CD8+ T cells.

 

It is likely that direct antigen presentation by the thyroid may occur in individuals who inherit T cells; such a circumstance would skip the standard mechanism. The HLA-DR antigen-expressing thyroid cell may be as successful as the macrophage at introducing thyroid-specific antigens to the immune system, but the thyroid cell is incapable of supplying the costimulatory signals that practitioner antigen-presenting cells (APCs) do. Any stimulus that causes increased DR expression on thyrocytes, for example IFN-? produced by T cells in response to infection, combined with increased TSH stimulation may allow thyrocytes to function properly. Though thyroid cells can perform this function they are localized, allowing for production of the previously established occurring low levels of antibodies, leading to autoimmune thyroid disorder in the human body.

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900Green-Call-Now-Button-24H-150x150-2.png

 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

 

blog picture of cartoon paperboy big news

 

TRENDING TOPIC: EXTRA EXTRA: About Chiropractic

 

 

Post Disclaimer

Professional Scope of Practice *

The information herein on "The Prevalence of Autoimmune Disease on the Thyroid | Wellness Clinic" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card

Again  We Welcome You¸

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training, and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists, and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, unwanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING!

Welcome & God Bless

EL PASO LOCATIONS

East Side: Main Clinic*
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Central: Rehabilitation Center
6440 Gateway East, Ste B
Phone: 915-850-0900

North East Rehabilitation Center
7100 Airport Blvd, Ste. C
Phone: 915-412-6677

Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
My Digital Business Card

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone
: (915) 850-0900
EmailSend Email
WebDrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
EmailSend Email
WebElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
EmailSend Email
WebChiropracticScientist.com

Just Play Fitness & Rehab*

Address: 7100 Airport Blvd, Suite C
El Paso, TX 79906
Phone: (915) 850-0900
EmailSend Email
WebChiropracticScientist.com

Push As Rx & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone
: (915) 412-6677
EmailSend Email
WebPushAsRx.com

EVENTS REGISTRATION: Live Events & Webinars*

(Come Join Us & Register Today)

Call (915) 850-0900 Today!

Rated Top El Paso Doctor & Specialist by RateMD* | Years 2014, 2015, 2016, 2017, 2018, 2019, 2020 & 2021

Best Chiropractor In El Paso

Scan QR Code Here - Connect Here With Dr. Jimenez Personally

Qrcode Chiropractor
Dr. Jimenez QR Code

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form:  bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment:  bit.ly/functionmed

Disclaimer *

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

phone: 915-850-0900

Licensed in Texas & New Mexico *

Dr. Alex Jimenez DC, MSACP, CIFM, IFMCP, ATN, CCST
My Digital Business Card

Post Disclaimer

Professional Scope of Practice *

The information herein on "Fighting Inflammation Naturally *Chiropractic Care* | El Paso, Tx (2023)" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.

Blog Information & Scope Discussions

Our information scope is limited to Chiropractic, musculoskeletal, acupuncture, physical medicines, wellness, contributing etiological viscerosomatic disturbances within clinical presentations, associated somatovisceral reflex clinical dynamics, subluxation complexes, sensitive health issues, and/or functional medicine articles, topics, and discussions.

We provide and present clinical collaboration with specialists from various disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and directly or indirectly support our clinical scope of practice.*

Our office has reasonably attempted to provide supportive citations and has identified the relevant research studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez, DC, or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, RN*, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License # TX5807, New Mexico DC License # NM-DC2182

Licensed as a Registered Nurse (RN*) in Florida
Florida License RN License # RN9617241 (Control No. 3558029)
Compact Status: Multi-State License: Authorized to Practice in 40 States*

Presently Matriculated: ICHS: MSN* FNP (Family Nurse Practitioner Program)

Dr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
My Digital Business Card